The Bills announced that wide receiver Marquez Valdes-Scantling is out after suffering a neck injury in the second quarter.
The veteran receiver recorded one reception for eight yards in the Saturday's game in Pittsburgh.
Valdes-Scantling signed a one-year contract with the Bills in March after spending the last two seasons with Kansas City. Valdes-Scantling is in his seventh NFL season.
QB Mitchell Trubisky (knee), DT Austin Johnson (calf), TE Quintin Morris (shoulder) and DE Javon Solomon have also been ruled out for tonight's game.
Check out the best photos from the Bills' second preseason game. This gallery is presented by Gabe's Collision.