- The Bills defense leads the NFL in two categories – rushing yards per game allowed (71.0) and third down efficiency (31.8%) ... The Bills are tied for the NFL lead with a +6 turnover margin (New England, San Diego and Green Bay).
- The Buffalo Bills are one of two NFL teams (NY Jets) with three players with 3.0 or more sacks (Marcell Dareus 5.0, Mario Williams 3.5 and Jerry Hughes 3.0).
- Marcell Dareus posted a personal single-game high of 3.0 sacks. His sack total is the highest single-game total for a defensive player in the AFC.
- Kyle Orton became the first Bills quarterback to throw for 300 yards (308) since Ryan Fitzpatrick (337) at New England 11/11/12.
- Orton is the fifth NFL quarterback since 1960 to record a 300-yard passing game with five teams in his career joining Kerry Collins, Steve Deberg, Gus Frerotte, and Vinny Testeverde.
- Orton also tied a team record by completing passes to 10 different receivers (Ryan Fitzpatrick vs. Tennessee 12/4/11).
- Sammy Watkins' 24 receptions in his first five games is tied for the most by a Bills rookie (Jerry Butler in 1979).
- With seven receptions, Fred Jackson became the first Bills running back to produce six-plus receptions in three consecutive games.
- Jackson also combined for 107 scrimmage yards to produce his 32nd career 100-plus scrimmage yardage game.
- Dan Carpenter 58-yard game-winning kick was the longest in the NFL in the last 10 seconds of the fourth quarter since Josh Scobee's 59-yard field on October 3, 2010 (for Jacksonville against Indianapolis).
- Carpenter's kick was also the second-longest in team history (Steve Christie 59 yards vs. Miami 9/26/93) and the second-longest of his career (60-yarder w/ Miami vs. Cleveland 12/5/10).
- Carpenter is now the Bills all-time leader in field goal accuracy percentage at 90.19 % (46 of 51). Rian Lindell is second at 83.33 % (225 of 270).