ORCHARD PARK, N.Y. (AP) -Peyton Manning will make his 192nd straight start, though the Colts are resting numerous starters, including defensive ends Dwight Freeney and Robert Mathis, for their season finale.
Freeney, cornerback Jerraud Powers, defensive tackle Antonio Johnson and right tackle Ryan Diem are among the Colts ruled out against Buffalo (5-10) on Sunday. Indianapolis (14-1), the AFC's top playoff seed, also lists numerous starting lineup changes by sitting out Mathis, linebacker Clint Session, safety Melvin Bullitt and left tackle Charlie Johnson.
Manning is expected to see limited action, then be replaced by rookie backup Curtis Painter.
Weather will play a factor, with snow falling and a frigid wind plunging temperatures into the teens.