It's the first game without Fred or C.J. in 1,485 days.

It's hard to remember the Bills before Fred Jackson or C.J. Spiller came onto the scene, and that's because it was a very long time ago - 1,465 days to be exact. That's the last time the Bills dressed for a game without either Fred or C.J. as the starting running back. On October 3, 2010 against the Jets, Marshawn Lynch was the starter.

It's Dan Carpenter's 100th game.

Celebrate that century mark with a win, Dan! It would only be fitting. We'll bring the snacks if you bring the scores and celebration.

Positive bye-week vibes will go far.

With a win, the vibes during the upcoming bye week would be – needless to say – uber positive. It would mark the second straight season and second total time since 1999 that we'd be heading into the bye with a win. Two weeks of bliss could be headed our way.

It would be the Bills first win at MetLife.

MetLife Stadium opened in 2010, and let's just say the Bills haven't had the best luck of all-time in that venue. The team has played the Jets four times and the Giants once and have yet to tally one in the win column, but they'll look to change their luck this Sunday.

Doug Marrone looks to prove his luck against Geno Smith.

On the flipside, luck is in the Bills favor as head coach Doug Marrone prepares his team for Geno Smith, who he's seen twice in the pros and once in college. His Syracuse Orange routed Smith and the Mountaineers in the Pinstripe Bowl to end Marrone's final season with 'Cuse, and despite a close loss at MetLife, the Bills beat up on the Geno and the Jets at the end of the 2013 season at home. Safe to say Marrone knows how to prep his team for the young QB.

It's Hogan's homecoming.

Last week, Chris Hogan was a hero in the final minute of the game when he caught a long ball from Kyle Orton and landed on the 1-yard line to setup a Sammy Watkins touchdown to win the game. This week, Hogan will get a hero’s welcome not only for last week's in-game heroics, but because it's a homecoming for the New Jersey native. He'll have 20 to 30 family and friends in attendance.

Spikes and Hughes would like bragging rights.

Brandon Spikes and Jerry Hughes will both take on college teammates, and we're sure they'd like to be able to talk a little trash after the game to old friends. Spikes' fellow Florida Gator is the Jets newest acquisition, WR Percy Harvin, and Hughes' fellow TCU Horned Frog is WR Jeremy Kerley.

It'll solidify that blue pants are the best pants on the road.

Call them crazy, call them flashy, call them extreme, but you know deep inside you're in love with the Bills blue pants. The team will be wearing blue pants and white jerseys for the second time in a row on the road, and last time they came up big in a win against the Lions. A second road win in a row in the blue and white would prove that they're the best way to go for away games.

It should be a milestone day for Kyle Orton.

With only 81 yards, Orton will hit the 16,000 yard mark in his veteran career.