AP: 49ers vs. Bills

Buffalo Bills quarterback Ryan Fitzpatrick (14) looks to pass against the San Francisco 49ers during the first quarter of an NFL football game, Sunday, Oct. 7, 2012, in San Francisco. (AP Photo/Tony Avelar)

Buffalo Bills running back C.J. Spiller (28) runs against San Francisco 49ers linebacker NaVorro Bowman (53) during the first quarter of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

San Francisco 49ers wide receiver Kyle Williams (10) runs past Buffalo Bills cornerback Aaron Williams (23) to score on a touchdown pass from quarterback Alex Smith during the second quarter of an NFL football game, Sunday, Oct. 7, 2012, in San Francisco. (AP Photo/Tony Avelar)

San Francisco 49ers tight end Vernon Davis (85) runs past Buffalo Bills defensive back Justin Rogers (26) during the second quarter of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

San Francisco 49ers head coach Jim Harbaugh yells during the second quarter of an NFL football game against the Buffalo Bills in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

Buffalo Bills tight end Scott Chandler, left, fumbles the ball as he is tackled by San Francisco 49ers linebacker Patrick Willis during the second quarter of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. San Francisco safety Dashon Goldson recovered the ball. (AP Photo/Ben Margot)

San Francisco 49ers wide receiver Michael Crabtree (15) catches a touchdown pass from quarterback Alex Smith in front of Buffalo Bills cornerback Stephon Gilmore (27) during the second quarter of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

Buffalo Bills head coach Chan Gailey talks with quarterback Ryan Fitzpatrick (14) during the second quarter of an NFL football game against the San Francisco 49ers, Sunday, Oct. 7, 2012, in San Francisco. (AP Photo/Ben Margot)

San Francisco 49ers running back Frank Gore scores on a touchdown run against the Buffalo Bills during the third quarter of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Ben Margot)

San Francisco 49ers quarterback Colin Kaepernick (7) is tackled by Buffalo Bills safety Jairus Byrd (31) and cornerback Stephon Gilmore during the third quarter of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Ben Margot)

Buffalo Bills wide receiver T.J. Graham (11) tries to run past teammate Donald Jones (19) on a reception against the San Francisco 49ers during the third quarter of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

San Francisco 49ers tight end Vernon Davis (85) cannot make a catch over Buffalo Bills free safety Jairus Byrd (31) during the third quarter of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

San Francisco 49ers quarterback Colin Kaepernick (7) runs for a touchdown against the Buffalo Bills during the fourth quarter of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

Buffalo Bills cornerback Aaron Williams (23) dives to tackle San Francisco 49ers quarterback Alex Smith during the fourth quarter of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

Buffalo Bills wide receiver T.J. Graham (11) sits on the bench during the fourth quarter of an NFL football game against the San Francisco 49ers in San Francisco, Sunday, Oct. 7, 2012. The 49ers won 45-3. (AP Photo/Ben Margot)

Buffalo Bills cornerback Aaron Williams (23) and defensive end Alex Carrington (92) tackle San Francisco 49ers quarterback Alex Smith during the fourth quarter of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)