Isaiah McKenzie's 37-yard catch and run

Watch all of Buffalo Bills running back James Cook's best plays from his 120-yard game in an AFC East-clinching win over the visiting San Francisco 49ers on "Sunday Night Football" during Week 13 of the 2024 NFL regular season.

Watch all of Buffalo Bills quarterback Josh Allen's best plays from his 3-touchdown game on "Sunday Night Football" against the visiting San Francisco 49ers in Week 13 of the 2024 NFL regular season.

Watch all of the Buffalo Bills' top plays from their AFC East-clinching win over the visiting San Francisco 49ers on "Sunday Night Football" during Week 13 of the 2024 NFL regular season.

Bills won their 5th consecutive AFC East title. Watch highlights from the Week 13 matchup between the San Francisco 49ers and the Buffalo Bills during the 2024 NFL season.

Buffalo Bills Jalen Virgil pounces on San Francisco 49ers wide receiver Deebo Samuel's fumble as the Bills' 'Sunday Night Football' avalanche continues.

Buffalo Bills tight end Dawson Knox follows up a contested 17-yard grab by making snow angels on the field.

Josh Allen rushes for an 8-yard touchdown vs. San Francisco 49ers, 12/01/2024

Buffalo Bills wide receiver Amari Cooper pitches to Bills quarterback Josh Allen for an improvised hook-and-ladder touchdown.

Kyle Juszczyk fumbles after a Taylor Rapp punch out, Christian Benford recovers vs. Buffalo Bills, 12/01/2024

Josh Allen with a 7-yard touchdown pass to Mack Hollins vs. San Francisco 49ers. Allen passed Jim Kelly for the franchise record in total touchdowns with 245.

Buffalo Bills tight end Dawson Knox takes San Francisco 49ers safety Ji'Ayir Brown for a ride on a 39-yard catch and run.

Buffalo Bills edge Greg Rousseau chases down San Francisco 49ers quarterback Brock Purdy to boosts his 2024 NFL regular season sack total to 6.5.

James Cook rushes for a 65-yard touchdown vs. San Francisco 49ers, 12/01/2024

Ray Davis rushes for a 5-yard touchdown vs. San Francisco 49ers, 12/01/2024. Fans throw snow in celebration of the game's first touchdown.

Here's everything you need to know when the San Francisco 49ers play the Buffalo Bills Week 13 of the 2024 NFL season.

From wild Josh Allen throws to amazing runs from the Running Backs, re-live every single Bills touchdown from the 2024 season as we head into the bye week.

Hear Highmark Stadium's roar from the sideline view of Josh Allen's 26-yard touchdown run on fourth down against the Chiefs to give the Bills a 30-21 lead in the fourth quarter. More highlight available on BuffaloBills.com.

Buffalo Bills quarterback Josh Allen best plays from 317-yard game | Week 11.

Watch highlights from the Week 11 matchup between the Kansas City Chiefs and the Buffalo Bills during the 2024 NFL season. Bills ended Kansas City's 15-game winning streak with a 30-21 win.

Can't-Miss Play: Linebacker Terrel Bernard ices Buffalo Bills' win vs. Kansas City Chiefs on late INT vs. Patrick Mahomes.

Can't-Miss Play: Buffalo Bills quarterback Josh Allen's CLUTCH touchdown run on fourth down boosts Bills' lead to 29-21.

Curtis Samuel catches for a 12-yard Touchdown vs. Kansas City Chiefs, 11/17/2024. His first touchdown as a Bill and 30th career touchdown.

Kicker Tyler Bass' 33-yard FG gives Buffalo Bills a 16-14 lead over Kansas City Chiefs entering halftime.

Buffalo Bills defensive back Brandon Codrington's 25-yard punt return vs. Kansas City Chiefs nearly goes for a lot more.

Buffalo Bills defensive end Ed Oliver and linebacker Von Miller collapse pocket vs. Kansas City Chiefs quarterback Patrick Mahomes for third-down sack.