It's the last chance for some players on the back half of the squad to make a case for a spot on the 53-man roster. A big performance against the Bears could merit more consideration from the personnel department and coaching staff.
Here's a look at some who will be looking to do just that.
OL Alec Anderson
The second-year player, who was on Buffalo's practice squad as a rookie has positioned himself well to be part of the 53-man roster. A backup, who now has experience at center, guard and tackle, must continue to demonstrate that versatility against Chicago and it could land him an offensive line spot this fall.
DE Kameron Cline
On Buffalo's practice squad last season, Cline has taken a big leap forward with his play this summer. From affecting the quarterback off the edge to heads up play on special teams covering kicks, the first-year player is pushing young vets like Boogie Basham and A.J. Epenesa for a roster spot. Another head-turning performance against Chicago might steal him one.
WR Tyrell Shavers
After an up and down performance in the preseason opener, which included a touchdown reception, the undrafted rookie out of San Diego State got 20 snaps last week but managed just two targets and one reception. Shavers must smooth out the consistency of his game if he's going to make a play for the active roster.
DT Kendall Vickers
Another player with time served on the Bills practice squad, Vickers had some dominant snaps last week at Pittsburgh. With a stacked defensive tackle room, Vickers has an uphill battle, but has certainly been disruptive and physical in the preseason. That could position him on the practice squad as an early call up this season in the event of injury.
TE Joel Wilson
The undrafted rookie out of Central Michigan has put together a steady camp and preseason, but he'll need to flash a bit more in the passing game if he's going to finish higher on the depth chart than other tight end reserve Jace Sternberger. Their snaps have been close through the first two preseason games both on offense and special teams. Wilson must be the more productive player because a practice squad spot could be riding on it.