The Bills signed the following 17 players to the practice squad on Sunday.
- OT Trey Adams
- TE Nate Becker
- OL Evan Boehm
- DE Bryan Cox Jr.
- TE Jason Croom
- DB Dane Jackson
- DB Cam Lewis
- DE Mike Love
- OT Victor Salako
- LB Andre Smith
- DB Josh Thomas
- RB Christian Wade
- T Brandon Walton
- QB Davis Webb
- RB Antonio Williams
- WR Duke Williams
- DT Justin Zimmer
Practice squads can include a total of 16 players in 2020. The new CBA increased it from 10 to 12, and then the amended COVID rules added four more spots.
Christian Wade returns to the practice squad as the team's 17th member since he is part of the NFL international players program.