Mike Rodak's pick: This game has the potential to be sloppy between two teams that rank in the top six in turnovers lost and in the top nine in turnovers forced. It seems reasonable to lean in the direction of Andrew Luck over Derek Anderson and in favor of the home team. But one bounce the Bills' way could change the outcome. Colts 17, Bills 14
Mike Wells' pick: The Colts are off to their worst start since the 2011 season. The only positive outside of Luck's play this season is that they could have receiver T.Y. Hilton (hamstring) back for the first time since Week 4. Hilton's return will help a group that has 13 drops in the past three games. Scoring will be tough, as Buffalo is ranked 10th in total defense. Colts 17, Bills 10
