Mike Reiss' pick:The Patriots haven't played a game this season without committing a turnover, and that is the Bills' best hope at pulling the upset, similar to what they did in Minnesota earlier this season. In the end, the Patriots' offensive firepower should be enough against an underwhelming Bills attack in a game that could be closer than many anticipate. Patriots 30, Bills 20
Mike Rodak's pick:The Bills' offense has scored more than 20 points in only one game this season, while the Patriots' offense has scored fewer than 20 points only once. It is going to take either an outlier performance from either of those units, or scoring from Buffalo's defense or special teams for the Bills to pull off an upset. Other than a high snap to Andrew Luck last Sunday that went for a safety, neither the Bills' defense nor special teams have scored this season. Patriots 34, Bills 17
